For instance, PFKFB3 may modulate AP severity by controlling acinar cell-mediated Ca2+ overload (Zhang et al. 2024a, b), and may prevent the progression of severe AP via the Nrf2/HO-1 signaling pathway in macrophages (Ergashev et al. 2024). The gene discussed is PFKFB3; the disease is alkaline phosphatase measurement.