PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3), a key regulatory enzyme in the glycolysis pathway, has garnered attention for its role in AP (Jiang et al. 2023a, b; Sun et al. 2023; Yang et al. 2023). This evidence concerns the gene PFKFB3 and alkaline phosphatase measurement.