To further investigate the detailed information between TRIM47 and ADAR, we applied treatment with a proteasome inhibitor MG132 to differentiated thyroid carcinoma FTD-133 cells combining with the short hairpin RNAs with TRIM47-#1 and Sh-TRIM47-#2 specific against TRIM47, and the TRIM47 overexpression. The gene discussed is ADAR; the disease is thyroid gland carcinoma.