While GSK-3β was knocked down with the short hairpin RNAs (shRNA) sh-GSK-3β specific against GSK-3β in anaplastic thyroid carcinoma THJ-29 T cells, it triggered the increase of expression abundance of ADAR and the decrease of the hyperphosphorylation of ADAR compared to sh-mock via immunoprecipitation IP (Fig. 6C and D). Here, GSK3B is linked to thyroid gland undifferentiated (anaplastic) carcinoma.