In our study, we focus on the TRIM47 function in TC oncogenesis, and providentially, we found that a critical involvement of ADAR is linked to the accomplishment of TRIM47 through ADAR-associated ubiquitination and the GSK-3β-associated phosphorylation on TRIM47 and ADAR in thyroid cancer oncogenesis. Here, TRIM47 is linked to thyroid gland carcinoma.