RBM45 and lung carcinoma: To further clarify the target genes co-regulated by circ0515 and RBM45, we performed RNA sequencing on A549 lung cancer cells with knockdown of circ0515 and RBM45, identifying 680 and 327 significantly downregulated differential target genes (LogFC < 1, p < 0.001), respectively (Fig. 6G, H).