Finally, we identified a set of prognosis-associated biomarkers for each group including EpCAM, CEACAM1, CEACAM5, and CEACAM6 for CRLM-SD, DCN, TIMP3, and OLFM4 for CRLM-CA and FMO3, CES2 and AGXT for CRLM-OM. Here, CES2 is linked to ocular melanoma.