To distinguish CRC-LM subgroup CRLM-OM from the others in clinical diagnostic, flavin-containing monooxygenase 3 (FMO3), cocaine esterase (CES2) and alanine-glyoxylate aminotransferase (AGXT) may be of potential use (Fig. 6C). This evidence concerns the gene CES2 and colorectal carcinoma.