Among them, expression levels of pyruvate dehydrogenase kinase 1 (PDK1) and pyruvate kinase 2 (PKM2), which are associated with aerobic glycolysis and growth in cancer cells (37, 38), acyl-coenzyme A synthase short-chain family member 2 (ACSS2) (39), and eIF5A2 were upregulated; however, the expression levels of only a few genes related to oxidative phosphorylation (OXPHOS), autophagy, and TCA cycle were modulated (Fig. S2). This evidence concerns the gene PKM and cancer.