Notably, it is well known that Th2-mediated inflammation and eosinophilic infiltration represent hallmark pathological characteristics of CRSwNP,22, 23, 24 thereby the precise interplay between Bcl2L12 expression and the pathophysiology of CRSwNP remains an area warranting further investigation. This evidence concerns the gene BCL2L12 and chronic rhinosinusitis with nasal polyps.