Moreover, elevated Bcl2L12 exacerbates type 2 inflammation by promoting the differentiation of CD4 + T cells into the Th2 phenotype.32, 33 Consequently, we posited that environmental stimuli activate and enhance Bcl2L12 secretion by nasal mucosal epithelial and inflammatory cells within nasal polyps. This evidence concerns the gene CD4 and Nasal polyposis.