GSR and Cognitive impairment: However, in an intracerebroventricular-streptozotocin-induced Alzheimer’s model in rats with cognitive impairment, naringenin was found to enhance GSH, glutathione reductase (GR), glutathione peroxidase (GSH-Px), SOD, and CAT to detoxify 4-HNE in the hippocampus [44].