HOTTIP and cancer: We used GEPIA database (a) to compare HOTTIP expression between top 10 most common cancer types and paired normal tissue as shown in Fig. 1, (b) to explore the correlation between HOTTIP expression and overall survival in these cancers as seen in Fig. 2, and (c) to identify top 5 genes that have similar expression pattern to HOTTIP in the mentioned cancer types and this can be seen in supplementary table (S1).