In accordance with the RATIO study, we did not find any association between aCL and CIS in young women, but the overall presence of aCL remained lower in patients (low titer 9.3% and medium-to-high titer 1.9%) than in the 2015 systematic review (22%).5,6 Notably, over half of the studies in the latter analysis used a low aCL cutoff value. Here, ACLY is linked to in situ carcinoma.