Other genes, including WNT5A (AUC = 0.935), GCA (AUC = 0.922), ANXA6 (AUC = 0.909), ARPC3 (AUC = 0.909), and IL1β (AUC = 0.766) also exhibited heterogeneous levels of predictive precision for detecting osteosarcoma. Here, ARPC3 is linked to osteosarcoma.