It was also observed upregulation of Nrf2 and its target proteins such as HO‐1, decreased expression of proinflammatory cytokines TNFα and IL‐6, and reduced phosphorylation of STAT3, a proinflammatory transcription factor that enhances cell growth through c‐Myc and cyclin D1, promoting inflammation and cancer. This evidence concerns the gene STAT3 and cancer.