Our findings showing an excessive expression of markers of oxidative stress and vascular disorders in mice lacking ECs Opa1 agree with previous studies showing that a disequilibrium between fusion and fission occurs in cardiovascular diseases (Freed et al., 2014; Kadlec et al., 2016; Marin‐Garcia & Akhmedov, 2016; Ong et al., 2010). The gene discussed is OPA1; the disease is cardiovascular disorder.