CTSH and diabetic maculopathy: Multivariable MR analysis further confirmed the independent causal role of Cathepsin H in PDR {inverse variance weighted (IVW): p = 0.003, OR = 1.054, 95% CI = 1.017–1.093} and diabetic maculopathy (IVW: p = 0.022, OR = 1.068, 95% CI = 1.009–1.130).