A study reported in Cancer Cell in 2014 showed an increased abundance of intrahepatic CD8+ T and NKT cells in a mouse model of choline-deficient high-fat diet (CDHFD)-induced MASH; the phenotype was canceled in RAG1 knock out (KO) mice (lacking T cells, B cells, and NKT cells) and β2mKO mice (with non-functional CD8+ T cells and NKT cells), suggesting the involvement of CD8+ T cells in MASH [23]. This evidence concerns the gene RAG1 and metabolic dysfunction-associated steatohepatitis.