CD4 and neoplasm: These results suggested that BIRC2 expression was slightly associated with CD4+ T cell infiltration only in the TCGA dataset (Fig. 2E), while high BIRC3 expression was accompanied by high infiltration state of Tregs, macrophages and DCs (Fig. 2D&F, Fig. S4B&D), which are essential for antigen presentation and the activation of T cells leading to immune evasion by suppressing anti-tumor immune responses.