The results showed that M1 was predominantly enriched in polycomb repressive complex pathways, while M2 was primarily associated with processes such as protein processing in the endoplasmic reticulum, transcriptional misregulation in cancer, coronavirus disease (COVID-19), the AGE-RAGE signaling pathway in diabetic complications, and legionellosis (Fig. 6L). The gene discussed is RENBP; the disease is COVID-19.