We report several novel associations of proteins with percent emphysema (e.g., protein FAM177A1, syntenin-2, USP25, and uncharacterized protein C20orf173) as well as known ones (e.g., apoptosis regulator Bcl-2, sRAGE, IL1RN, ROBO2, adiponectin, and HMGB1) that together may provide new insights into disease pathophysiology and drug targets. This evidence concerns the gene USP25 and pulmonary emphysema.