Analysing the correlation between active phospho-IGF1R protein expression and prognosis using the TCGA TRGated RPPA dataset of ESCC tumour tissue, high median expression of phospho-IGF1R (pY1135/pY1136) was significantly correlated with both poorer OS (p = 0.042, HR, 2.46) (Fig. 3b) and disease-specific survival (p = 0.02, HR, 4.34) (Fig. 3c) of ESCC patients (n = 78) while no significant difference was observed in EAC (n = 48) (data not shown). The gene discussed is IGF1R; the disease is esophageal squamous cell carcinoma.