CD2 and neoplasm: For example, similar to EGFR-BBζ + CD2 CAR-T cells, compared with EGFR-BBζ CAR-T cells, these cells both presented lower levels of exhaustion-associated markers on day 19 postinfusion, maintained a greater number of CAR-T cells (not observed in tumor tissue), and secreted greater amounts of cytotoxic granules (Fig. 6D–F).