Based on RNA-seq reads that spanned exon-exon junctions originated from 2 distinct genes (Fig. S1A), we identified a fusion transcript of PLEKHA1 and TACC2 on chromosome 10q26 in one ESCC (ESCC 1), with the relatively high number of reads among the fusion transcripts (Figs. S1B, 1A). The gene discussed is PLEKHA1; the disease is esophageal squamous cell carcinoma.