The median leukocyte iScores increased from least cytotoxic to most cytotoxic immunephenotypes14 and were highest in interferon gamma (IFNg) and inflammatory clusters (C2,C3) and lowest in immune quiet cluster (C5)17 (Figs. 1C, S1C), showing consistent patterns with published immune subtypes of cancer (Anova p < 2e−16). This evidence concerns the gene IFNG and cancer.