The top 50 differentially expressed genes (DEGs) in the severe-risk and intermediate-risk groups compared with the moderate-risk group include the heart-disease-associated genes, that is, proenkephalin (PENK), transforming growth factor beta 2 (TGFB2) and natriuretic peptide precursor A (NPPA) and B (NPPB). Here, PENK is linked to heart disorder.