The elevated sTfR and sTfR/log ferritin in the P group have been previously reported as good biomarker of iron deficiency anemia even during inflammatory condition31.The anemia notified by reduction of plasma ferritin and the increase of sTfR and sTfR/log ferritin in PD model in the present research might occur due to disturbance in iron distribution, transport, storage and circulation in PD as reported previously7. The gene discussed is TFRC; the disease is Parkinson disease.