We previously reported three RASGRF1 fusions: (1) an OCLN–RASGRF1 fusion in an otherwise driver-negative lung adenocarcinoma from an individual with no smoking history, (2) an SLC4A4–RASGRF1 fusion in a KRAS wild-type human PDAC cell line, and (3) an IQGAP1–RASGRF1 fusion from a giant cell sarcoma characterized in The Cancer Genome Atlas (TCGA)21. Here, SLC4A4 is linked to lung adenocarcinoma.