Furthermore, our results showed that after MG132 treatment of CCA cells, the decrease of ROCK2 level had no significant effect on Drp1 expression, while after lysosome inhibitor Leupetin treatment of CCA cells, the decrease of ROCK2 level would still lead to the decrease of Drp1 expression (Fig. S10B, C). The gene discussed is DNM1L; the disease is cholangiocarcinoma.