ROCK2 and neoplasm: As shown in Figs. 7G–J and S15G, H, mice harbouring ROCK2-silenced cells exhibited a notable decrease in tumour weight and volume; however, the simultaneous knockdown of ROCK2 and UBA52 completely abolished the antitumour effect of Pemigatinib in ROCK2-knockdown cells; no significant difference in the total weights of the mice was observed before and after cell implantation.