Notably, those showing co-expression of ROCK2 and Drp1 were grouped together; compared to the results obtained based on ROCK2 or Drp1 levels independently, the simultaneous expression of ROCK2 and Drp1 served as an independent risk factor and a more sensitive indicator of poor prognosis across all CCA subtypes (Fig. 4M–P). The gene discussed is ROCK2; the disease is cholangiocarcinoma.