Recent studies have linked mutations in the gene that encodes for Gαo (GNAO1) to early infantile epileptic encephalopathies/developmental epileptic encephalopathies, diseases whose mechanisms remain to be elucidated at the molecular level (17, 18, 19, 20, 21, 22). The gene discussed is GNAO1; the disease is developmental and epileptic encephalopathy.