Our results demonstrate that C. jejuni infection induced human IFNγ production in the colon of THX and hu-PBMC-NSG humanized mice, consistent with increased IFNγ levels in C. jejuni-infected human patients.62 Although the intestinal inflammation driven by C. jejuni was mild in humanized mice, it recapitulates the self-limiting infection during human campylobacteriosis in healthy individuals. Here, IFNG is linked to campylobacteriosis.