As IL-22 is critical for epithelial cell regeneration in C. difficile colitis,46 inhibiting JAK/STAT signaling during later stages of infection may impair mucosal healing, as previously reported in DSS-induced colitis.45 Therefore, further studies are needed to define how JAK/STAT inhibition affects epithelial repair during C. difficile and other enteric infections. The gene discussed is SOAT1; the disease is colitis.