To assess the impact of tofacitinib treatment on the sensitivity to intestinal infection induced by human enteric pathogen C. jejuni, we utilized IL-10 deficient mice (IL-10 KO), a well-established mouse model of chronic intestinal inflammation.12,13 IL-10 KO mice were treated with antibiotic cocktail for 7 days to promote bacterial colonization. Here, IL10 is linked to inflammation.