The MASLD-associated genetic variantPNPLA3rs738409 (Patatin-like phospholipase domain-containing protein 3) has been investigated as it is clinically associated with more severe MASLD phenotypes and progression to fibrosis and represents an example of genetic heterogeneity found in MASLD patients.70, 71, 72LAMPS were constructed with genotyped wild type (CC) and high-risk GG (I148M) variant PNPLA3 human hepatocytes together with the three nonparenchymal cells. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.