Indeed, DDR1i caused differential expression in several direct RUNX1 target genes including DUT, an essential nucleotide metabolism enzyme seen upregulated across breast cancers (Davison et al., 2021), and MYC, along with ANP32B, PLEC, CEBPD, ID1, and STAT3 (Figures 3D, 3E, and S3C–S3G). Here, PLEC is linked to breast carcinoma.