PSEN1 and early-onset autosomal dominant Alzheimer disease: To confirm that day 60 human retinal organoids derived from Alzheimer’s disease human induced pluripotent stem cells (iPSCs), harboring familial genetic mutations in APP (Swedish) and PSEN1 (M146V), are capable of recapitulating disease features such as the production of amyloid-β species, we performed immunofluorescence using an antibody specific for amyloid-β and ELISA for amyloid-β (41, 42) (fig.