Using mice with a floxed conditional ‘tagged’ allele of the Rpl22 ribosomal protein expressed after crossing the mice to cell- or tissue-specific Cre driver lines [12], studies have assayed gene expression in hypothalamic neurons through TaqMan assays [47], Sertoli and Leydig cells of the testes through microarrays [20], proneural gliomas through ribosomal footprinting on translatome RNA [48], factor VII expression in endothelial cells through qPCR [49], and endothelial gene expression during homeostasis and inflammation through RNA-sequencing [50]. The gene discussed is F7; the disease is central nervous system cancer.