Indeed, if NCL is weakly expressed in the host of the infection, as a result, the maintenance and transcription of EBV episome will be compromised but, as a direct consequence of the role of NCL in GAr-based limitation of EBNA1 expression, EBNA1 mRNA will be more efficiently translated, which may compensate for its reduced level, thereby allowing the maintenance of EBV genome. Here, NUCLEOLIN is linked to infection.