T cells are also major targets that MTB interacts and their extensive transcriptome and cell receptor programming in TB are described.[335, 338, 339, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361] Further, gene biomarkers of exhausted T cells (CD4+ T cells: H1FX, ZFP36L2, VIM, and PPP1R15A; CD8+ T cells: ITM2C),[335] and 24 TCR similarity groups correlated to TB control[338] are summarized. Here, CD4 is linked to tuberculosis.