At the molecular level, the importance of IFN signaling has been repeatedly emphasized.[31, 283, 284, 285, 286, 287, 288] For instance, during infection, upregulated lncRNA‐GM inhibits GSTM1‐TBK1 interaction by directly binding to GSTM1, thereby interfering with GSTM1‐mediated S‐glutathione of TBK1. The gene discussed is GSTM1; the disease is infection.