CD8A and tuberculosis: For instance, a novel cluster, named CD8+ γδ T cells, is identified in patients with chronic MTB infection, and these cells are hyporesponsive to TCR‐mediated signaling but can generate strong CD16‐mediated cytolytic responses.[336] And CD16‐mediated cytolytic response is one of the major ways NK cells function and is critical for controlling MTB infection, suggesting that CD8+ γδ T cells may exert their protective action in TB‐like NK cells.