ISG15 and Sepsis: During sepsis, the proportions of hematopoietic stem cells, myeloid cells, and T cells significantly decrease, while neutrophils expand remarkably.[375, 376, 377, 378, 379] Transcriptionally, some myeloid subpopulations exhibit high expression of damage‐associated molecular pattern related‐ and IFN‐γ signaling related‐genes (e.g., S100A8 and ISG15).[375] Specifically, CD52 in lymphocytes is significantly elevated, showing a potential association with improved prognosis in sepsis patients.