In conditions like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), PANoptosis in innate immune cells (e.g., dendritic cells) may promote the release of self‐antigens, disrupt immune tolerance, and exacerbate inflammation via signaling pathways such as IL‐6/JAK‐STAT3 [16, 27]. The gene discussed is IL6; the disease is systemic lupus erythematosus.