Dysfunction of the human orthologs of Ham, PRDM16 (Mel1) and PRDM3 (Evi1, MECOM), has been found in a variety of human abnormalities including congenital diseases, metabolic disorders and cancers (Bard-Chapeau et al., 2012; Zhou et al., 2016; Corrigan et al., 2018; Cibi et al., 2020; Kundu et al., 2020; Horvath and Scheele, 2022; Wang et al., 2022; Hurwitz et al., 2023). The gene discussed is MECOM; the disease is metabolic disease.