This study is the first to systematically identify TMGs closely linked to the prognosis of CRC at the whole-genome level and to construct a CRC prognostic risk model consisting of seven key TMGs (CDC25C, CXCL1, RTL8C, FABP4, ITLN1, MUC12, and ERI1). This evidence concerns the gene CXCL1 and colorectal carcinoma.