Taken together, these results suggest that aging has differential effects on integrated estradiol regulation of VMNdm Ghrh neuron function during hypoglycemia, as relative ER variant gene expression is brought into alignment (as opposed to young animals) by reductions in proportional GPER gene expression in old males versus amplification of ERα and ERβ gene expression ratios in aged females. The gene discussed is ESR1; the disease is Hypoglycemia.