VMNdm Ghrh neurons also express hypoglycemia-responsive genes that encode metabolic-sensory biomarkers (i.e., the glucose sensor glucokinase and catalytic subunit of the ultra-sensitive energy sensor 5′-AMP-activated protein kinase [61]) and, in addition to Ghrh mRNA, transcripts for biosynthetic enzyme surrogates of characterized counterregulatory-constraining (γ-aminobutyric acid) or -enhancing (glutamate; nitric oxide) neurochemicals [60]. Here, GHRH is linked to Hypoglycemia.