Outcomes provide novel evidence that these neurons contain mRNA that encodes aromatase protein and that baseline expression of these transcripts is higher in old versus young rats of either sex, inferring that VMN Ghrh neuron neuroestradiol production may be enhanced with age, but cellular sensitivity to this local hormone signal may change during eu- and/or hypoglycemia. The gene discussed is CYP19A1; the disease is Hypoglycemia.