CD47 and neoplasm: The TME is populated by a significant number of tumor‐associated macrophages (TAMs), primarily of the M2 phenotype, which contribute to pro‐tumor activities.[58] Recent studies have demonstrated that TAMs and other phagocytes take up a big proportion of the injected LNPs, limiting their access to tumor cells.[59] One potential strategy to mitigate nonspecific uptake by TAMs could be the incorporation of “don't‐eat‐me” signals like CD47 motifs in the LNP surface.