Increased TREM1 and cytokine signaling pathways reflect the inflammatory burden in DLB, while mitogen‐activated protein kinase (MAPK)/extracellular signal‐regulated kinase 1/2 (ERK1/2), and AKT serine/threonine kinase 1 (AKT1) activation points to cellular survival mechanisms compensating for synaptic loss (Supplementary Material 18). This evidence concerns the gene AKT1 and Lewy body dementia.