The GFAP-IFNhi mice have been studied in the context of cerebral interferonopathies, with core clinical and pathological features of Aicardi-Goutières Syndrome (AGS) accurately recapitulated in GFAP-IFNhi mice (Aicardi and Goutières, 1984; Crow et al., 2015; Lebon et al., 1988). This evidence concerns the gene GFAP and Aicardi-Goutieres syndrome.