While the GFAP-IL6 mice (as well as the GFAP-IL6-IFNlo mice) are not an animal model of NMOSD (Duan and Verkman, 2020), as characteristic features of NMOSD including optic neuritis and AQP4-IgG-mediated astrogliosis have not been reported, our findings align with recent evidence that IFN-I can exacerbate IL-6-driven inflammation, such as that observed in NMOSD. The gene discussed is AQP4; the disease is optic neuritis.