GFAP and Ataxia: Conversely, chronic and elevated levels of IFN-α in the CNS of GFAP-IFNhi mice lead to epileptic seizures, ataxia and increased mortality, accompanied by severe neuropathological changes, including progressive encephalopathy, calcification, and microangiopathy (Akwa et al., 1998; Campbell et al., 1999; Viengkhou et al., 2024a; Viengkhou et al., 2024b).