Despite this, the disease in the double transgenic mice lacked key features of IFN-I-instigated neuroinflammation that are seen in GFAP-IFNhi mice (Akwa et al., 1998; Campbell et al., 1999; Viengkhou et al., 2024b) or individuals with AGS (La Piana et al., 2016; Viengkhou et al., 2024a; Viengkhou et al., 2024b) including reduced growth, convulsive seizures and calcifications. The gene discussed is GFAP; the disease is Aicardi-Goutieres syndrome.