Interestingly, middle cerebral artery occlusion (MCAO) animals (an ischemic stroke model) have worsen meningeal lymphatic drainage and the animals with ablation MLVs or mutational VEGFR-3 get more grievous stroke injury after MCAO, however, the stroke mice induced by photothrombosis show meningeal lymphangiogenesis (145, 146). Here, FLT4 is linked to stroke disorder.