With the effort to delineate the role of the G-Protein Coupled Receptor 116 (GPR116) receptor on NK cell function and on enhancing antitumor activity, GPR116-/- mice efficiently eliminated pancreatic cancer by enhancing NK cell proportion and targeting PC tumor through the Gαq/HIF1α/NF-κB signaling pathway (83). Here, ADGRF5 is linked to pachyonychia congenita.