showed adoptive transfer of syngeneic mouse T cells with a CAR which contains only the NKG2D ectodomain and CD3ζ domain, leads to long-term tumor-free survival in ID8 ovarian tumor-bearing mice, generation of both CD4+ and CD8+ ID8-specific T cells, and protection against ID8 tumor challenge and rechallenges (15). The gene discussed is KLRK1; the disease is neoplasm.