PLK1 can also exert a synergistic effect with FOXM1 to affect the prognosis of liver cancer (56), papillary thyroid cancer (57), bladder cancer (58),diffuse large B-cell lymphoma (59), kidney cancer (60), lung cancer (61), breast cancer (62), esophageal cancer (63) and other tumors. The gene discussed is PLK1; the disease is breast cancer.