PLK1 and Familial prostate cancer: Other transcription factors regulated by PLK1 include PLK1 phosphorylation-dependent REST degradation in triple-negative breast cancer (52), SUZ12 and ZNF198 in hepatitis B virus (HBV)-mediated liver cancer (53), and transcription of the key tumor suppressor FOXO1 in prostate cancer cells and rhabdomyosarcoma (54, 55).