For instance, WNT7B (CASP14, CALML5+ HPV-associated CA cluster) and FZD1 (conventional dendritic cells (cDCs)) were coexpressed, indicating the aggressiveness of the cancer; CEACAM5 (CASP14, CALML5+ HPV-associated CA cluster) and CD1D (cDC) were coexpressed, demonstrating tumor-associated antigen presentation; Furthermore, the coexpression of TNFSF10 (CASP14, CALML5+ HPV-associated CA cluster) and TNFRSF11B (macrophage) revealed tumor escape through antiapoptosis, fully characterizing the malignant nature of the cancer. Here, CALML5 is linked to neoplasm.