AKT1 and neoplasm: Thus, curcumin inhibits the growth of breast cancer cells by a variety of mechanisms, particularly triggering cell cycle arrest and p53-dependent apoptosis; altering the expression of signaling proteins such as Akt, PI3K, Ras, and mTOR; downregulating transcription factors; and suppressing tumor expansion and angiogenesis in MCF-7 breast cancer cell lines [92] (Fig. 9).