The reduction of collagen could enhance immune cell infiltration into tumor tissue by the following events: NAT to treat pancreatic cancer, specifically oxaliplatin and radiation, potently induce immunogenic cell death (ICD) and scattering tumor-associated antigens, which may recruit intratumoral DC-SIGN (+) dendritic cells, which possess promising antigen presentation potential. This evidence concerns the gene CD209 and familial pancreatic carcinoma.