The number of T-bet (+) T cells significantly increased in patients who received NAT p < 0.001) (Fig. 3B) whereas GATA-3 and ROR-γt (+) lymphocytes were both minor populations in the pancreatic cancer microenvironment; therefore, it was difficult to compare the histological changes (data not shown). This evidence concerns the gene BRD2 and familial pancreatic carcinoma.