Remodeling effect on the tumor microenvironment: Single-cell RNA sequencing (scRNA-seq) analysis of immune cell dynamics within tumor tissues indicated that SynOV markedly elevated the infiltration of CD8+ T cells, reduced the presence of immunosuppressive regulatory T cells, and fostered a shift toward antitumor M1 macrophages while diminishing CAFs within the TME. Here, CD8A is linked to neoplasm.