METTL3 and neoplasm: For instance, METTL3 is essential for the development and maintenance of myeloid leukemia in both mice and humans [13], modulates the Wnt/β-catenin-EMT axis in ESCC by stabilizing β-catenin/TCF4 transcriptional complexes to facilitate tumor invasion [14], and facilitates TGFβ signals to support tumor growth [15].