METTL3 and liver cancer: We acknowledge the limitations of the study as follows: (1) Lack of in vivo data to validate our in vitro findings; (2) The regulation of m6A on IRF1 expression remained to be explored; (3) It is unlikely that c-Src kinase acted as the sole factor that participated in METTL3-regulated liver cancer cell proliferation, due to METTL3 has been reported to modulate multiple factors in cells through its m6A modification activities.