MYC and breast cancer: The data objectively indicated that MYC knockdown obviously reversed the promoting effects on the proliferation, migration, and invasion of BC cells by upregulating circACTN4, whereas the inhibitory effects of circACTN4 silencing were rescued by MYC overexpression in BC cells, as determined via CCK8, EdU and Transwell assays (Fig. 5B–E and Fig. 6A–D).