Notably, the novel combination regimens of C(GC)•Mem(TRZ)•Zn exhibited a synergistic enhancement (CI < 1) of selective anti-ATPase efficacy (EI > 1) for Cis and 5FU against both Na+-K+-Mg2+ATPase (Table 4, Fig. 4) and Mg2+-ATPase (Table 5, Fig. 5) in the aforementioned cancer cell lines. Here, DNAH8 is linked to cancer.